Objective: To study pharmacokinetics of veratric acid in rats. Method: Veratric acid was administrate to rats by oral gavage

blood samples were collected at various time points

HPLC was adopted to determine the content of veratric acid in blood samples by taking 3

4-dihydroxybenzoic acid methyl ester as an internal standard

mobile phase of acetonitrile(A)-1% acetic acid(B) (0-11 min

5%-57%A;11-13 min

57%-5%A)

detection wavelength was set at 256 nm

plasma concentration-time curve was drawn

pharmacokinetic parameters were calculated by Kinetica 4.4 software. Result: After oral gavage administration

veratric acid existed secondary peak phenmenon in rats

Tmax were (45.00±10.00) and (31.00±8.22) min

respectively;Cmax of high and low dose groups were (176.85±28.89) and (68.14±12.58) mg·L-1

t1/2 were (87.74±20.74) and (227.18±93.78) min

AUC0-∞ were (50 363.50±11 667.7) and (18 830.32±4 354.35) min·mg·L-1

MRT0-∞ were (201.39±16.72) and (227.40±21.37) min

respectively. Conclusion: Veratric acid had a long in vivo acting time due to its quick absorption and slow elimination.