Objective: To explore the possible mechanism of Liqi Xiaoying tablet on rat goiter. Method: Sprague Dawley (SD) rats were randomly divided into six groups:normal control group

model group

Liqi Xiaoying tablet low

middle and high dose group

euthyrox group. In addition to the normal control group

the rest of the rats in each group were fed daily propylthiouracil (20 mg·kg-1) to establish the model

Liqi Xiaoying tablet low

middle and high dose group were fed simultaneously 2.4

4.8

9.6 g·kg-1 of Liqi Xiaoying tablet solution

positive drug group was given 7.8 μg·kg-1 of euthyrox. Sixty days later the animals were sacrificed and serum thyroid tissue specimens were collected. Rat thyroid index calculation

serum free triiodothyronine (FT3)

free thyroxine (FT4)

thyroid-stimulating hormone (TSH) levels

thyroid pathological changes were observed

immunofluorescence staining was used to saasy thyroid tissue basic fibroblast growth factor (bFGF)

B cell lymphoma/lewkmia-2(Bcl-2)

transforming growth factor beta (TGF-β) expression changed. Result: Compared with normal group

in model group

serum FT3

FT4 levels increased (P<0.05)

TSH decreased (P<0.05)

significantly enlarged

thyroid (P<0.01)

bFGF

Bcl-2 expression was significantly increased

TGF-β expression was significantly decreased. Compared with model group

Liqi Xiaoying tablet could significantly reduce goiter index (P<0.05)

but change of serum FT3

FT4

TSH levels was not obvious

reduced the pathological changes of the thyroid

bFGF

Bcl-2 expression (P<0.01)

elevated TGF-β expression (P<0.01). Conclusion: Liqi Xiaoying tablet has the role of anti-goiter

its mechanism may be associated with bFGF

Bcl-2

TGF-β.