Objective: The purpose is to observe the clinical curative effect of Huoxue Tongluo decoction in the cooperation with uterine hydrotubation in the tubal infertility and its influence on tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)and blood rheology. Method: Ninety-four cases of patients were randomly divided into control group (45 cases) and observation group (49 cases) according to the digital method. Patients in the control group adopted the uterine Hydrotubation. based on this

patients in the observation group took Huoxue Tongluo decoction with add and subtract treatment

1 dose/day

conventional water decoction

about 200 mL/time

taking in the morning and the night. the treatment course of two groups is two months. The patients took one year follow-up

recording pregnancies condition (including rate of intrauterine pregnancy

ectopic pregnancy rate and pregnancy abortion rate).The uterus oviduct images were taken to evaluate the tubal patency before and after treatment. The levels of TNF-α and IL-6 and blood rheology before and after the treatment were detected. Result: The intrauterine pregnancy rate of observation group is 40.8%

which is better than 20.0% of control group (P<0.05). The comparison of ectopic pregnancy rate and pregnancy abortion rate of two groups does not have statistically significant differences. the tubal patency rate of observation group is 63.3%

which is better than 42.2% of control group (P<0.05). the levels of serum TNF-α and IL-6 was decreased after treatment

while the more significant decline occurred in the observation group (P<0.01). the improvements of whole blood viscosity (low

medium

high)

whole blood reductive viscosity (low

medium and high shear)

erythrocyte aggregation index and plasma viscosity of observation group after treatment were all better than control group (P<0.01). Conclusion: Huoxue Tongluo decoction cooperated with uterine hydrotubation can promote the fallopian tube recanalization

increase intrauterine pregnancy rate. The immediate and long-term efficacy is significant. The mechanism may be related to reduce inflammatory damage

promote inflammation absorption

and improve microcirculation in the pelvic region.