Objective: To observe the effects of the Tianlong compound on patients with influenza A. Method: Nasopharyngeal swab specimens were collected from the individual who had developed influenza-like-symptoms

and Flu A NP antigen was rapidly tested using dot immunoenzyme filtration assay(DIEFA)

then the influenza virus A RNA of the positive samples were detected using quantitative real time reverse-transcription polymerase chain reaction (qRT-PCR).Positive samples were finally diagnosed with the influenza A. The diagnosed 58 cases with influenza A infection were randomly divided into traditional Chinese medicine(TCM) group(25 cases

taking Tianlong compound)

control group (25 cases

taking symptom relief medicine only)and tamiflu group(8 cases

taking tamiflu(phosphoric acid oseltamivir).The treatment durations in the three groups were three days

then the differences among the three groups on curative effects

the duration of fever and the Ct value of the influenza A virus RNA were analyzed before and after treatment. Result: The curative effect of each case in the TCM group was obviously higher than that in the control group

and the difference was significantly statistical(P<0.05)

but there was no difference between the TCM group and the tamiflu group.The duration of fever in the TCM group and the tamiflu group was shorter than that in the control group(P<0.05)

however

there was no significant difference between the TCM group and the tamiflu group.Compared with the prior treatment

the Ct value of the influenza A virus RNA was increased after treatment in the TCM group and the tamiflu group

the difference was both statistically significant(P<0.05)

but without significant difference between the two groups. Conclusion: The Tianlong compound was effective in shortening the duration of fever

relieving symptoms and reducing the number of the influenza virus.