Objective: To study the influence of Gegen Tongmaiyin to plasma nuclear factor-kappaB(NF-κB) in patients with atherosclerosis

and explore its curative effect and mechanism. Method: Ninty-seven patients were randomly divided into control group and Gegen Tongmaiyin group(treatment group).Rosuvastatin was used to cure patients of control group.On the basis of this conventional treatment

Gegen Tongmaiyin was added to cure patients of treatment group

water decoction

one dose a day.After 8 weeks

plasma total cholesterol(TC)

triglycerides(TG)

high density lipoprotein(HDL)

low density lipoprotein(LDL)

apolipoprotein A(ApoA)

ApoB

lipoprotein(a)(Lpa) were detected by automatic biochemical analyzer. Plasma NF-κB was measured by ELISA. Philips ie33 ultrasound machine was used to measure carotid intima-media thickness (IMT) and Carotid atherosclerosis plaque integral. Result: Compared with before treatment

plasma TC

TG

LDL-C

ApoB

Lpa strikingly decreased

and HDL strikingly increased(P<0.05

P<0.01).Compared with the control group

plasma TC

LDL-C

ApoB of treatment group significantly decreased after combination treatment with rosuvastatin and gegentongmaiyin (P<0.05).Which indicated curative effect of the combination of rosuvastatin and Gegen Tongmaiyin was superior to conventional treatment in curing atherosclerosis. Carotid intima-media thickness (IMT) and carotid atherosclerosis plaque integral showed atherosclerotic plaque of treatment group significantly diminished compared with before treatment and control group (P<0.05). Plasma NF-κB of treatment group significantly reduced in contrast to control group(P<0.01). Conclusion: Gegen Tongmaiyin can effectively adjust blood lipid levels

and then intervene the occurrence and development of Atherosclerotic plaque.Downregulating plasma NF-κB may be its mechanism of how to preventing atherosclerosis.