Objective: To observe the clinical efficacy of the treatment of Jianpi Qingre Huayu decoction on the patients with precancerous lesion of gastric carcinoma and discuss the possible mechanism of the prescription. Method: Sixty cases were divided into control group and treatment group (n=30 each)

according to their clinical number. In the treatment group Jianpi Qingre Huayu decoction was given to the patients with one decoction divided into 2 times daily and in the control group Weifuchun tablets were given 4 pills every time and three times a day. Clinical effect

symptoms integral

endoscopic images

pathological changes integral and the helicobacter pylori eradication rate were observed in each group. the expression of mucin 5 AC protein in every group was investigated using immunohistochemistry. Result: The clinical effect

endoscopic images

and the effect on pathological changes in treatment group were better than in the control group

having significant difference (P<0.05). the helicobacter pylori eradication rate in treatment group was 65.0% was higher than in control group

which was 26.3%(P<0.05). After treatment the symptoms and pathological changes integral in treatment group decreased more than in control group(P<0.01). the MUC5 AC protein expression in treatment group MUC5 AC increased more than in control group(P<0.05). Conclusion: The treatment of Jianpi Qingre Huayu decoction improved the symptoms in patients with precancerous lesion of gastric carcinoma and may prevent the development of precancerous lesion of gastric carcinoma.the mechanism of this function maybe relate to the increase of the expression of MUC5 AC protein.