Objective: To investigate the clinical effect of Bufei Yishen treatment of idiopathic pulmonary interstitial fibrosis caused by chronic respiratory failure. Method: In this study

idiopathic pulmonary interstitial fibrosis caused by chronic respiratory failure patients were randomly divided into study group and control group. The control group took the routine treatment measures. The study group was given Bufei Yishen traditional Chinese medicine and therapy method above. The clinical efficacy and blood gas index were compared between two groups. Result: The total efficiency of study group (90.32%) was significantly higher than those in control group (67.74%) (P<0.05). The main index of patients in the two groups after treatment SaO2

PaO2

PaCO2

HCO3

pH and blood gas were significantly improved after treatment

but the study group improved significantly better than the control group (P<0.05). Conclusion: While the conventional western medicine foundation treatment with Bufei Yishen decoction

curative effect of IPF induced lung and kidney deficiency type chronic respiratory failure

which can effectively improve pulmonary function. It has certain advantages than the pure western medicine treatment

and is the treatment of chronic obstructive pulmonary disease is safe and effective.