Box-Behnken设计-效应面法优选防风炮制工艺

刘婵; 张水寒; 黄惠勇; 秦裕辉; 肖娟; 蔡萍; 万丹

doi:10.11653/syfj2014050018

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Box-Behnken设计-效应面法优选防风炮制工艺

更新时间：2024-01-04

- Box-Behnken设计-效应面法优选防风炮制工艺
- Optimization of Processing Technology for Saposhnikoviae Radix by Box-Behnken Design-Response Surface Methodology
- 中国实验方剂学杂志 2014年20卷第5期页码：18-21
- 作者机构：
- 作者简介：
- 基金信息：
  
  湖南省科技厅重点项目（2012TF1005）
- DOI：10.11653/syfj2014050018
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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刘婵, 张水寒, 黄惠勇, 等. Box-Behnken设计-效应面法优选防风炮制工艺[J]. 中国实验方剂学杂志, 2014,20(5):18-21.

LIU Chan, ZHANG Shui-han, HUANG Hui-yong, et al. Optimization of Processing Technology for Saposhnikoviae Radix by Box-Behnken Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 18-21.
刘婵, 张水寒, 黄惠勇, 等. Box-Behnken设计-效应面法优选防风炮制工艺[J]. 中国实验方剂学杂志, 2014,20(5):18-21. DOI： 10.11653/syfj2014050018.

LIU Chan, ZHANG Shui-han, HUANG Hui-yong, et al. Optimization of Processing Technology for Saposhnikoviae Radix by Box-Behnken Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 18-21. DOI： 10.11653/syfj2014050018.

摘要

目的：优选防风的炮制工艺。方法：以升麻素苷和5-O-甲基维斯阿米醇苷含量、浸膏得率、水分的综合评分为指标，采用Box-Behnken设计-效应面法考察切片厚度、干燥时间、干燥温度对防风饮片质量的影响，优选防风饮片的炮制工艺参数。结果：最佳炮制工艺为切片厚度3~4 mm，干燥温度60 ℃，干燥时间2 h。升麻素苷和5-O-甲基维斯阿米醇苷的质量分数分别为0.917%，0.054%，水分5.110%，浸膏得率20.45%。结论：采用Box-Behnken设计-效应面法优选的炮制工艺合理可行，为防风饮片的质量控制提供参考。

Abstract

Objective: To optimize processing technology of Saposhnikoviae Radix. Method: Taking composite score of contents of prim-O-glucosylcimifugin and 5-O-methylvisammioside

extract yield

water contents as index

effects of slice thickness

drying time and drying temperature on pieces quality were investigated by Box-Behnken design-response surface methodology

so as to optimize processing technology parameters of Saposhnikoviae Radix. Result: Optimal processing parameters were as follows:slice thickness 3-4 mm

drying temperature at 60 ℃

drying time 2 hours.Under these conditions

contents of prim-O-glucosylcimifugin and 5-O-methylvisammioside

extract yield

water contents were 0.917%

0.054%

20.45% and 5.110%

respectively. Conclusion: Optimized processing technology for Saposhnikoviae Radix was feasible and reasonable

it could provide a reference for quality control of Saposhnikoviae Radix pieces.

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