Objective: Reveal the composition of acidic components and its biological activity of Schisandra chinensis. Method: Using organic solvent extraction

macroporous resin separation and solvent treatment to prepare acidic components from S. chinensis

HPLC were applied for qualitative and quantitative analysis. Meanwhile

the influence of acidic components in swimming time

resistance to atmospheric oxygen

weight of immune organs and influence of immune phagocytosis in mice were observed. Result: The acidic components were mainly consisted of citric acid

quinic acid and other organic acids

the total amount of two acids were reached 55.8%. Low dose (5 g·kg-1)sour substance could significantly prolong the swimming time of mice (P<0.001) and the thymus index

spleen index compared with the control group enhance significantly in mice (P<0.05

P<0.01); high and low dose sour substance can be notably increase the mouse peritoneal macrophage phagocytic function to improve the phagocytic index and phagocytic coefficient K value of a value; especially

there was a significant difference between the low dose group and normal control group (P<0.001

P<0.01). Conclusion: Acidic componnets of S.e chinensis with anti-fatigue and immune enhancement effect better

is an important component of S. chinensis pharmacodynamic material bases.