抗柯萨奇B病毒性心肌炎胶囊复方新制剂对病毒性心肌炎小鼠血清TNF-,IL-6的影响

马会霞; 徐静; 李洁; 姚荣妹; 陈超逸; 包巨太

doi:10.11653/syfj2014050137

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抗柯萨奇B病毒性心肌炎胶囊复方新制剂对病毒性心肌炎小鼠血清TNF-,IL-6的影响

更新时间：2024-01-04

- 抗柯萨奇B病毒性心肌炎胶囊复方新制剂对病毒性心肌炎小鼠血清TNF-,IL-6的影响
- Effect of New Formulation of K-CoxB-JN Compound on TNF- and IL-6 in Mice with Coxsackie B3 Viral Myocarditis
- 中国实验方剂学杂志 2014年20卷第5期页码：137-140
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技重大专项“重大新药创制”课题（2009ZX09103-442）;河北省科技厅项目（101Z6426P）;河北省中医药管理局项目(2017212)
- DOI：10.11653/syfj2014050137
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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马会霞, 徐静, 李洁, 等. 抗柯萨奇B病毒性心肌炎胶囊复方新制剂对病毒性心肌炎小鼠血清TNF-,IL-6的影响[J]. 中国实验方剂学杂志, 2014,20(5):137-140.

MA Hui-xia, XU Jing, LI Jie, et al. Effect of New Formulation of K-CoxB-JN Compound on TNF- and IL-6 in Mice with Coxsackie B3 Viral Myocarditis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 137-140.
马会霞, 徐静, 李洁, 等. 抗柯萨奇B病毒性心肌炎胶囊复方新制剂对病毒性心肌炎小鼠血清TNF-,IL-6的影响[J]. 中国实验方剂学杂志, 2014,20(5):137-140. DOI： 10.11653/syfj2014050137.

MA Hui-xia, XU Jing, LI Jie, et al. Effect of New Formulation of K-CoxB-JN Compound on TNF- and IL-6 in Mice with Coxsackie B3 Viral Myocarditis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 137-140. DOI： 10.11653/syfj2014050137.

摘要

目的：探讨抗柯萨奇B病毒性心肌炎胶囊复方新制剂（K-CoxB-JN）对病毒性心肌炎小鼠血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）的影响及其机制。方法：用CVB3感染Balb/c小鼠造成病毒性心肌炎模型，随机分为5组：K-CoxB-JN复方新制剂低、中、高剂量组（0.2，0.4，0.8 g·kg-1），利巴韦林组（0.075 g·kg-1），模型组，并设正常组，鼠腹腔接种病毒2 h后开始灌胃，连续灌胃14 d。观察小鼠一般状态、记录死亡数，计算小鼠生存率；取血测定血清TNF-α，IL-6水平；取心脏，计算心脏指数，HE染色，计算病理积分。结果：与正常组比较，模型组小鼠血清TNF-α，IL-6水平、心脏指数、心脏病理积分均升高（P<0.05），生存率降低（P<0.05）；与模型组比较，K-CoxB-JN各组小鼠心脏指数，TNF-α，IL-6水平、心脏病理积分均降低（P<0.05），生存率升高（P<0.05）。结论：调节TNF-α，IL-6水平可能是K-CoxB-JN治疗病毒性心肌炎作用机制之一。

Abstract

Objective: To investigate the effect and its mechanisms of the new formulation of K-CoxB-JN compound on tumor necrosis factor-α(TNF-α) and interleukine(IL)-6 in mice with coxsackie B3 viral myocarditis. Method: The mice were injected with CVB3 to establish the experimental model of viral myocarditis

then randomly divided into 5 groups:The new formulation of K-CoxB-JN compound low

middle

high dose group (0.2

0.4

0.8 g·kg-1)

ribavirin group(0.075 g·kg-1)

the model group.and set up the normal group

two houres later mice were gavaged for 14 days. The general state of the mice were observed

deaths were recorded and calculated the survival rate of mice;the content of TNF-α

IL-6 were tested. Took heart and calculated the cardiac index

HE staining

calculated the pathological integral. Result: Compared with the normal group

the model group mice cardiac index

TNF-α and IL-6 level

the pathological integral were increased(P<0.05)

the survival rate were decreased(P<0.05)

Compared with the model group

the new formulation of K-CoxB-JN compound group mice cardiac index

TNF-α and IL-6 level

the pathological integral were decreased(P<0.05)

the survival rate were increased(P<0.05). Conclusion: Regulation of TNF-α

IL-6 level may be one of the mechanisms of the new formulation of K-CoxB-JN compound in the treatment of viral myocarditis.

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