ZHANG Zhong-liang, LI Qiang, LI Qiu-fen, et al. Study of Effect for Qishe Fang in Model Rats Dorsal Root Ganglion PLA, PGE Expression Based on Theory of Compatibility[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 166-171.
ZHANG Zhong-liang, LI Qiang, LI Qiu-fen, et al. Study of Effect for Qishe Fang in Model Rats Dorsal Root Ganglion PLA, PGE Expression Based on Theory of Compatibility[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 166-171. DOI: 10.11653/syfj2014050166.
Objective: To observe the model rat nerve root compression dorsal root ganglion neurons (DRG) inside phospholipase A2(PLA2)
prostagland in E2(PGE2) content of expression for different demolition party of Qishe Fang(QSF) and to further explore the compatibility law. Method: The 352 three-month-old SPF SD male rats were randomly divided into 11 groups
each group were administered simultaneously take dorsal root ganglia with different time PLA2 and PGE2 contents were detected by ELISA. The results were compared by SPSS 18.0
To identify the sensitivity component in inflammatory changes. Thus revealing the compatibility of components QSF interaction law suppressing inflammation. Result: Different compatibility groups relative to the untreated group can significantly reduce the dorsal root ganglion PLA2
PGE2 levels P<0.01
but between different groups with varying degrees of inhibition of inflammation P<0.05. Conclusion: Description of the compatibility between the components there is a synergistic effect
statistics showed that monarch drug can play a leading role
the other components can enhance the efficacy for monarch drug
but all parties comply the best efficacy compare others
the result indicating the compatibility of science and rationality of all parties.