Objective: To study of Shenqi Huafen Pian on exercise-induced fatigue in rats. Method: Seventy male SD rats were randomly divided into normal control group

model control group

Shenqi Huafen Pian high

medium

low dose groups(2.5

1.25

0.625 g·kg-1)

Nifedipine tablets groups(0.01 g·kg-1)

Ciwujia tablets groups (0.25 g·kg-1).Drugs were administered to mice for 9 days.Except control group

the other 6 groups were conducted exhaustive swimming experiment. The weight

MDA(malonaldehyde) and lactic acid(LD) content

adenosine triphosphatase(ATPase)

catalase(CAT)

Glutathione peroxidase(GSH-Px) and superoxidedismutase(SOD) activity were measured. Result: The weight in Shenqi Huafen Pian high

medium dose groups was increased(P<0.01).In high dose group of Shenqi Huafen Pian

Na+-K+-ATPase activity

Mg2+-ATPase and Ca2+-ATPase activity of liver cells were obviously increased compared with model(P<0.05)

GSH-Px activity in liver was significantly higher than that in model group(P<0.01)

activities of SOD in kidney were significantly higher than that(P<0.01).In high and middle dose group of Shenqi Huafen Pian

CAT activities in liver were significantly higher than that in model group(P<0.01)

MDA content in kidney was lower than that(P<0.01)

blood LD contents were obviously lower than that in model group(P<0.05). Conclusion: Shenqi Huafen Pian showed anti-fatigue effects.The effects could be mediated by increasing the ability of antioxidation and improving lactate metabolism.