Objective: The purpose is to observe the clinical curative effect of Xiaozheng decoction in uterine fibroids treatment and the influence of serum vascular endothelial growth factor (VEGF). Method: Eighty cases of patients were randomly divided into control group (40 cases) and observation group (40 cases) according to the doctor order.Patients in the control group took Guizhi Fuling pill

6 g/time

2 times/day.Patients in the observation group took Xiaozheng decoction add and subtract treatment

1 does/day.The treatment course of two groups was twelve weeks. Measure the fibroid volume before and after treatment.Record main symptoms and body score.Detect the sex hormone levels and serum VEGF level. Result: The comprehensive total effective rate of observation group was 92.5%

which was superior to control group (72.5%) (P<0.05). after treatment

the volume of uterus and the area of myoma of observation the group were lower than the control group(P<0.05)

there were no significant difference on the level of estradiol(E2)and progesterone(P)

the prolactin(PRL) of observation group was lower than the control group(P<0.01)

after treatment

the main symptom and sign integral of observation group were lower than the control group(P<0.01)

the level of serum (VEGF) of observation group was lower than the control group(P<0.01). Conclusion: The creation of Xiaozheng decoction is based on the center pathogenesis of uterine fibroid

the add and subtract treatment with clinical discrimination can relieve main clinical symptoms

symptoms score and reduce volume of uterus and area of myoma. There is a significant clinical effect and the mechanism may be related to relieving serum VEGF and PRL of patients.