Objective: To investigate the clinical effects and mode of action of Huazhuo Xuanfei decoction to treat middle and old age chronic bronchitis (CP) at acute attack. Method: Ninety-five cases of patients were randomly divided into control group (47 cases) and observation group (48 cases).The patients in control group took moxifloxacin hydrochloride tablets

0.4 g/time

1 does/day.Ambroxol hydrochloride tablets

30 mg/time

2 does/day

taken after meal.For patients in observation group

they took moxifloxacin hydrochloride tablets as the control group.Besides they were added Huazhuo Xuanfei decoction by dialectical add and subtract treatment

1 does/day

conventional water frying and drink it in two times.The treatment course was 10 days for both groups.Record the third

seventh

tenth day's cardinal symptom

size grading before and after treatment.Record onset time and response duration of main card cough and cough up phlegm.Detect the level of serum interleukin-2(IL-2)

interleukin-6(IL-6) and tumor necrosis factor alpha(TNF-α). Result: After treatment

comprehensive therapeutic effect in observation group and traditional Chinese medicine syndrome curative effect were superior to control group(P<0.05)

the effective rate of cough and expectoration in observation group were 72.92% and 70.83%

which were better than 51.06% and 46.81% of control group(P<0.05). At the third

seventh

tenth day

cardinal symptom and signs of integral in observation group were lower than control group after the treatment(P<0.05 or P<0.01)

points in cardinal symptom and signs of integral of observation group were superior to control group(P<0.01)

onset time and response duration of observation group were less than observation group(P<0.01)

after treatment

the serum IL-2 level was superior to observation group(P<0.01)

serum IL-6 and TNF-α level were inferior to observation group(P<0.01). Conclusion: Huazhuo Xuanfei decoction can reduce middle and old age chronic bronchitis' cough and cough up phlegm at acute attack quickly.Clinical curative effect is distinct.Its mode of action may be associated with the inhibition of inflammatory reaction and reduce damage of airway inflammatory.