栀子中效应成分的稳定性考察及减压提取工艺优选

伍振峰; 王雅琪; 杨明; 王芳; 黄娟; 韩丽

doi:10.11653/syfj2014060010

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栀子中效应成分的稳定性考察及减压提取工艺优选

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- 栀子中效应成分的稳定性考察及减压提取工艺优选
- Investigation of Stability and Optimization of Vacuum Extraction Technology for Active Constituents in Gardeniae Fructus
- 中国实验方剂学杂志 2014年20卷第6期页码：10-14
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81173565）;江西省教育厅项目（GJJ13603）
- DOI：10.11653/syfj2014060010
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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伍振峰, 王雅琪, 杨明, 等. 栀子中效应成分的稳定性考察及减压提取工艺优选[J]. 中国实验方剂学杂志, 2014,20(6):10-14.

WU Zhen-feng, WANG Ya-qi, YANG Ming, et al. Investigation of Stability and Optimization of Vacuum Extraction Technology for Active Constituents in Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 10-14.
伍振峰, 王雅琪, 杨明, 等. 栀子中效应成分的稳定性考察及减压提取工艺优选[J]. 中国实验方剂学杂志, 2014,20(6):10-14. DOI： 10.11653/syfj2014060010.

WU Zhen-feng, WANG Ya-qi, YANG Ming, et al. Investigation of Stability and Optimization of Vacuum Extraction Technology for Active Constituents in Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 10-14. DOI： 10.11653/syfj2014060010.

摘要

目的：考察栀子水提液中栀子苷、西红花苷I的稳定性并优选栀子的减压提取工艺参数。方法：采用经典恒温法考察栀子水提液中栀子苷、西红花苷I的稳定性。以栀子苷、西红花苷I含量及浸膏得率为因变量，提取温度、提取时间、料液比为自变量，利用Box-Behnken设计-效应面法优选提取工艺条件。结果：最佳提取工艺参数为提取温度45 ℃，提取时间60 min，料液比1：14；栀子苷质量分数3.51%，西红花苷I质量分数1.21%，浸膏得率28.24%，RSD分别为1.44%，2.21%，0.96%，各因变量与预测值偏差较小。结论：减压提取法适合药材中热敏性成分的提取，优选的减压工艺稳定可行，为栀子的综合利用开发提供实验依据。

Abstract

Objective: To investigate stability of geniposide and crocin-I in water extract of Gardeniae Fructus and optimize their vacuum extraction process. Method: Stability of geniposide and crocin-I in water extract was studied by classical constant temperature acceleration test.With extract yield

contents of geniposide and crocin-I as dependent variables

solid-liquid ratio

extraction temperature and time as independent variables

Box-Behnken design-response surface methodology was optimize vacuum extraction technology. Result: Optimal process parameters was as follows:extraction temperature 45 ℃

extraction time 60 min

ratio of liquid to solid 14:1;Under these conditions

extract yield

contents of geniposide and crocin Ⅰ were 28.24%(0.96%)

3.51%(1.44%) and 1.21%(2.21%)

respectively. Conclusion: Vacuum extraction method was suitable for Chinese herbals which contained heat-sensitive components.This optimized process was reasonable and practicable

which could provide useful reference for comprehensive utilization of Gardeniae Fructus.

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