Objective: To optimize molding process of Zhiyu granules and establish its quality standards. Method: With formability and dissolubility as indexes

molding technology of Zhiyu granules was optimized by single factor tests;TLC was used for qualitative identification of Gardeniae Fructus

Curcumae Radix and Coptidis Rhizoma;HPLC was adopted to determine the content of gardenoside with mobile phase of acetonitrile-water(10:90) and detection wavelength of 238 nm. Result: Optimal molding process was as following:ratio of herbs extract-stevioside-dextrin(10:1:1)

added 65% ethanol for made of soft materials

drying temperature at 55 ℃.Spots of Gardeniae Fructus

Curcumae Radix and Coptidis Rhizoma on TLC plates were clear without interference by the blank reference;Gardenoside showed a good linear relationship at the range of 3.28-16.40 mg·L-1

average recovery was 101.02% with RSD of 1.67%

the content of gardenoside should not less than 24.0 mg·g-1. Conclusion: Optimized process was simple

feasible and suitable for industrial production;This established quality control method was specific and reproducible

which could be adopted to quality control of Zhiyu granules.