Objective: To optimize decocting technology conditions of Guiyuan Yiqi Buxue decoction. Method: HPLC was adopted to determine contents of ferulic acid and astragaloside with mobile phases of methanol-0.05% phosphoric acid(60:40) and acetonitrile-water(33:67)

detection wavelength of 320 and 203 nm

respectively.Taking dry extract yield

contents of astragaloside and ferulic acid

yield of total polysacchrides as comprehensive evalutaion index

orthogonal test was used to optimize decoction conditions with solid-liquid ratio

decoction time and decoction times as factors. Result: Optimum decoction conditions were as follows:decocted 3 times with 12-fold water

36 minutes each time

soaked 30 min before decocting;Under these conditions

dry extract yield was 6.80%

extraction amount of astragaloside and ferulic acid were 68.17 and 18.24 mg·g-1

yield of total polysacchrides was 6.80%. Conclusion: This optimized decoction technology was stable and reproducible

which was suitable for industrial production of Guiyuan Yiqi Buxue decoction.