鲜地黄及保鲜加工品对血热出血模型大鼠凉血止血药效比较

贾秀梅; 张振凌; 吴瑞环

doi:10.11653/syfj2014060127

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鲜地黄及保鲜加工品对血热出血模型大鼠凉血止血药效比较

更新时间：2024-01-04

- 鲜地黄及保鲜加工品对血热出血模型大鼠凉血止血药效比较
- Effects of Fresh Rehmanniae Radix and its Processed Products on Blood of Fevered and Bleeding Rats
- 中国实验方剂学杂志 2014年20卷第6期页码：127-132
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家“十二五”科技支撑计划（2011BAI06B02）;国家中医药行业科研专项（20110700701）
- DOI：10.11653/syfj2014060127
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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贾秀梅, 张振凌, 吴瑞环. 鲜地黄及保鲜加工品对血热出血模型大鼠凉血止血药效比较[J]. 中国实验方剂学杂志, 2014,20(6):127-132.

JIA Xiu-mei, ZHANG Zhen-ling, WU Rui-huan. Effects of Fresh Rehmanniae Radix and its Processed Products on Blood of Fevered and Bleeding Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 127-132.
贾秀梅, 张振凌, 吴瑞环. 鲜地黄及保鲜加工品对血热出血模型大鼠凉血止血药效比较[J]. 中国实验方剂学杂志, 2014,20(6):127-132. DOI： 10.11653/syfj2014060127.

JIA Xiu-mei, ZHANG Zhen-ling, WU Rui-huan. Effects of Fresh Rehmanniae Radix and its Processed Products on Blood of Fevered and Bleeding Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 127-132. DOI： 10.11653/syfj2014060127.

摘要

目的：比较鲜地黄及其保鲜加工品对血热出血模型大鼠凉血止血作用的区别。方法：SD雄性大鼠80只，以干姜水煎剂15 g·kg-1灌胃结合5%乙醇代替自由饮水，联合给药15 d 建立大鼠血热出血模型，造模成功后将造模组动物随机分为模型组、云南白药组、鲜地黄组、鲜地黄汁组、鲜地黄粉组、鲜地黄颗粒组、鲜地黄饮片组，各组灌胃给予相应药物15 d，模型组给与等体积的蒸馏水，余下各组剂量分别为：0.66，9，9，2，9，2 g·kg-1。给药后观察各组大鼠摄食量、饮水量、粪便含水量的变化，以及舌、胃、肺部出血情况。通过测定全血及血浆黏度以及凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）含量等指标，考察鲜地黄及其保鲜加工品对模型动物血液系统的影响。结果：造模后大鼠肛温升高，饮水量明显增加，摄食量减少，体重减轻，粪便含水量明显减少（P<0.05，P<0.01）；全血高、中、低切黏度及血浆黏度明显增加（P<0.05，P<0.01）；凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）明显延长（P<0.05，P<0.01），纤维蛋白原（FIB）含量极显著增加（P<0.01）。灌胃给药鲜地黄及其加工品后大鼠热盛症状明显减轻，全血黏度和血浆黏度以及凝血功能指标（PT，TT，APTT，FIB）渐趋于正常。病理组织学观察发现，鲜地黄及其炮制加工品能够改善血热出血大鼠舌、肺、胃部出血损伤的相关症状。结论：鲜地黄及其保鲜加工品能够减轻血热出血大鼠的热象症状，改善异常的血液流变学、凝血系统指标，具有凉血止血功效。

Abstract

Objective: To compare the different effects of fresh Rehmannia Radix and its processed products on the blood of fevered and bleeding rats. Method: The rat blood heating and bleeding model were established by giving dose of 15 g·kg-1 decoction of Ginger combined with 5% ethanol for 15 days. After modeling

eighty SD male rats were randomly divided into model compared group

Yunnan Baiyao group

the Fresh Rehmanniae Radix group

the juice of Rehmanniae Radix group

the powder of Rehmanniae Radix group

the granule and decoction pieces of Rehmanniae Radix group. Every group was given corresponding drugs for 15 days.The dose was 0.66

2 g·kg-1.The following indexes were observed like appetite

amount of drinking water

water content of waste hemorheological parameters and the degree of bleeding about tongue

stomach and lung. By detect its blood and plasma viscosity

prothrombin time(PT)

thrombin time(TT)

activated partial thromboplastin time(APTT) and fibrinogen(FIB) to compare the effects of fresh Rehmannia Root and its processed products on the blood system. Result: The model group significantly elevated rectal temperature and the amount of drinking water

decreased the appetite

lost of weight

significantly reduced the content of fecal water(P<0.05

P<0.01)

increased high blood viscosity

middle blood viscosity

low blood viscosity and blood plasma viscosity(P<0.05

P<0.01)

significantly prolonged PT

APTT

TT(P<0.05

P<0.01)

significantly increased FIB(P<0.01).After being given with corresponding drugs

the series of heated symptoms of rats were obviously relieved

blood viscosity

blood plasma viscosity

APTT and FIB gradually go to normal level. By observed the pathological tissue

unprocessed and processed fresh R. glutinosa can improve the injured lung and stomach of blood of fevered and bleeding rats. Conclusion: fresh R. glutinosa and processed R. glutinosa can relieve blooding heating symptoms and bleeding in rats

and improve the abnormal hemorheological parameters and blood coagulation system.

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