Objective: To study effect of selenium(Se) yeast(Astragalus membranaceus fermentation product) on diabetes rats with immune-suppression. Method: Eighty SD rats

10 to the normal control group

70 rats to establish experimental immune-suppression and diabetic rat model and watch Se yeast on the effects of streptozotocin diabetes and cyclophosphamide immunocompromised rat.The successful model of the animal were randomly divided into 5 groups (n=10 each group): diabetic model with immune-suppression group

oxytetracycline tablets control group (0.1 g·kg-1)

yeast solution group (0.5 g·kg-1)

A.membranaceus extract group (5 g·kg-1)

Se yeast group (0.5 g·kg-1). Each group fixed feed

free drinking water. Four weeks after the last to give the corresponding drug

abdominal aortic blood

separation of serum

fasting blood glucose (FBG)

blood

immunoglobulin (IgG)

interleukin-2 (IL-2)

insulin (INS) level

and pancreatic histological observation and insulin like growth factor (IGF) were detected. Result: In the model group

FBG were significant difference to normal group FBG (P<0.01)

model group INS

WBC

IgG

IL-2 were statistically significant difference to normal group corresponding index (P<0.05). Se yeast group FBG

INS

WBC

IgG

IL-2 have statistical difference to the corresponding index in the model group (P<0.05). Se yeast group with compared other indicators have also improved with the model group. Conclusion: Se yeast can reduce FBG and increase the level of INS

also can enhance the WBC

IgG

IL-2 and other immune parameters

Se yeast can make the immunity of animal models of diabetes mellitus reduce blood sugar

enhance immunity. Extracted from the dregs of decoction of trace elements is a good way to use the development of a drug by fermentation technology.