Objective: To observe the compatibility of Huangqi Gegen decoction root have impact on blood glucose

blood lipid and interleukin-12(IL-12)

interleukin-15(IL-15) in rats with diabetes mellitus (DM)

and regulate the interaction between diabetes processes. Method: Sixty-six SD rats were randomly divided into 6 groups

normal group

model group (A1B1)

positive control group

Astragali Radix group (A2B1)

Puerariaelobatae Radix group (A1B2)

Huangqi Gegen decoction group (A2B2)

11 each group. In addition to the normal group and positive control group

the rest of the group were induced by Streptozotocin(STZ

46 mg·kg-1) made after the model according to the 2×2 factorial design experiment scheme. Positive control group by 1.47 g·kg-1 dose gavage

Astragali Radix group

Puerariaelobatae Radix group

Huangqi Gegen decoction group were 2.7 g·kg-1

1.35 g·kg-1

4.05 g·kg-1 dose ig 30 days.Blood lipid and the levels of IL-12 and IL-15 in liver of rats indicators

etc.Were detected related index to calculate the weighted composite score of comprehensive index using the factorial design analysis of variance method study astragalus and kudzu root main effect and interaction effect. Result: Compared with normal group

blood glucose

serum cholesterol

triglyceride

IL-12

IL-15 in liver of diabetes rats were increased significantly(P<0.05).Astragali Radix

Puerariaelobatae Radix and Huangqi Gegen decoction effectively reduce blood glucose

serum cholesterol

triglyceride(in addition to Huangqi Gegen decoctio)

IL-12 and IL-15(P<0.05). Conclusion: Puerariaelobatae Radix lowering blood sugar is good

no interaction with Astragali Radix

Huangqi Gegen decoction additive effect in terms of lowered blood sugar drug compatibility is not presented; comprehensive regulation in liver tissue cholesterol

triglyceride

concentration of IL-12 and IL-15

Astragali Radix and Puerariaelobatae Radix compatibility of the two drugs in combination is superior to single herbs.