抗老年性痴呆复方开心散有效提取物血清药物化学研究

刘学伟; 刘爽; 黄树明

doi:10.11653/syfj2014060179

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抗老年性痴呆复方开心散有效提取物血清药物化学研究

更新时间：2024-01-04

- 抗老年性痴呆复方开心散有效提取物血清药物化学研究
- Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease
- 中国实验方剂学杂志 2014年20卷第6期页码：179-183
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金青年基金项目（81303248）;黑龙江省教育厅海外学人科研项目（1153h18）;黑龙江省科技厅面上项目（LC2008C264）;哈尔滨市科技局科技创新人才研究专项基金项目（2013RFQXJ154）;黑龙江中医药大学科研基金面上项目（2010）
- DOI：10.11653/syfj2014060179
  中图分类号：
- 纸质出版日期：2014
- 稿件说明：
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刘学伟, 刘爽, 黄树明. 抗老年性痴呆复方开心散有效提取物血清药物化学研究[J]. 中国实验方剂学杂志, 2014,20(6):179-183.

LIU Xue-wei, LIU Shuang, HUANG Shu-ming. Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 179-183.
刘学伟, 刘爽, 黄树明. 抗老年性痴呆复方开心散有效提取物血清药物化学研究[J]. 中国实验方剂学杂志, 2014,20(6):179-183. DOI： 10.11653/syfj2014060179.

LIU Xue-wei, LIU Shuang, HUANG Shu-ming. Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 179-183. DOI： 10.11653/syfj2014060179.

摘要

目的：分析开心散60%乙醇提取物（KXS-60%E）体外各成分的归属来源及大鼠灌服KXS-60%E后药物入血成分。方法：应用UPLC-TOF-MS技术建立KXS-60%E体外成分以及大鼠灌服药物后含药血清样品的分析方法，根据各单味药的色谱峰确定全方主要成分的来源归属；对比空白血清、含药血清的成分异同，分析药物的入血成分。结果：通过对比KXS-60%E与各单味药的正负总离子流图，归属了94个主要色谱峰的来源；大鼠口服KXS-60%E后，在血中分析指定了41个入血成分，其中13个为新产生的代谢产物，28个成分为KXS-60%E的原形成分。结论：血中移行成分及其代谢产物是KXS-60%E防治老年性痴呆（AD）的更直接药效物质基础，对其进行深入的研究将有助于阐明开心散防治AD的作用机制。

Abstract

Objective: To analyse the origin of peaks in Kaixinsan(KXS) extracted by 60% ethano(KXS-60% E)l and the constituents in rat plasma after oral administration of KXS-60% E. Method: A UPLC-TOF-MS method for analyzing the constituents in KXS-60% E and in rat plasma after oral administration of KXS-60% E

has been established.The origin of peaks in KXS-60% E were pointed out compared with each single herb in the formula similarly

the origin of peaks in treated serum after oral KXS-60% E were identified by contrasting the control rat serum. Result: Ninty-four compounds were detected in KXS-60% E in vitro

by compare with control rat plasma

41 peaks were pointed out in treated plasma.Concluding 28 original form in KXS-60% E and 13 metabolites. Conclusion: The constituents absorbed into blood and their metabolites of KXS-60% E were the direct basis of action of the drug

further study on these constituents may clarify the mechanism of KXS prevention and treatment on Alzhemer's disease.

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