Objective: To prepare chitosan film as a carrier of colon-specific drug delivery system from Catharsius molossus. Method: Taking mechanical properties

moisture penetrability

swelling and acid resistance as indexes

single factor tests were adopted to optimize preparation technology with concentrations of acetic acid

glycerol and sodium hydroxide

drying conditions as factors. Result: The best process of film-forming were as follows:2% acetic acid as solvent

the concentration of chitosan 2%

2% sodium hydroxide as de-film agent

immersion time of 2 h

5% glycerol as plasticizer;Chitosan solution on glass plate was heated for 3 h at 40 ℃ firstly in process of film-forming

these prepared chitosan film had transparent appearance

uniform thickness

small moisture permeability and some resistance to acid with good mechanical properties and overall performance. Conclusion: This technology was stable and reliable

it could be used as a coating excipient in colon-specific tablets and may have wide application in other fields as a new material.