Objective: To optimize extraction process of total tannins from leaves of Apocynumm venetum. Method: With the content of total tannins as index

single factor test was used to investigate extraction methods

extraction solvent

solid-liquid ratio and other factors on extraction technology;With extract amount and yield of total tannins as comprehensive evaluation index

orthogonal test was used to optimize extraction technology of total tannins from leaves of A. venetum with liquid-solid ratio

extraction time and times as factors. Result: Optimum extraction process was A2B3C3

that was as following:reflux extracted 3 times with 20 times the amount of methanol

3 h each time. Conclusion: This optimized extraction technology was stable

reasonable and feasible

it could be as an industrial production technology for leaves of A. venetum.