Objective: To optimize extraction process of Magnolia officinalis by central composite design/response surface methodology. Method: Taking ethanol concentration

extraction time and the amount of solvent as independent variables

overall desirability of dry extract yield and the content of magnolol and honokiol as dependent variable

each level of independent variables was fitted by multiple linear regression and binomial formula fitting

extraction process was optimized by response surface method

and prediction was carried out through comparing the observed and predicted value. Result: Optimum extraction technology was as following:extracted 3 times with 10-fold the amount of 60% ethanol for 95 minutes each time. Conclusion: This optimized extraction technology of M. officinalis was reasonable

stable and feasible with high accuracy

it could be extended to large-scale production applications.