Objective: To observe the effect of Chuangxiong Dingtong grainules (CXDT) on promoting blood circulation to dissipate blood stasis. Method: Seventy-two Kuenming mice were randomly divided into sex groups: normal control group(A)

model group(B)

compound Danshen dripping pills group(C)

high-dose CXDT group(D)

middle-dose CXDT group(E)

low-dose CXDT group(F). Mice in group C-F were ig medicine 0.135

1.75

0.88

0.44 g·kg-1 for 3 days. 1:1 000 epinephrine hydrochloride was dropped to the auricle of mice to induce local microcirculation disturbance. BI-2000 medical image analysis system was used to observe the microcirculation of mice at 10

20

30 minutes after dropping epinephrine hydrochloride. Sixty SD rats were grouped and gavaged as Kuenming mice. The qi-stagnancy and blood stasis rat model were established by epinephrine hydrochloride subcutaneous injection and ice water immertion. The femoral arteriovenous mixed-blood was used to assay hemorheology. Result: CXDT could significantly accelerate the microvascular flow rate of auricle microcirculation

expand its microvascular vein caliber and micro-artery diameter(P<0.05)

increase the amount of open capillaries(P<0.05)

significantly reduce the whole blood viscosity and the high shear blood relative index of blood stasis rat mode(P<0.05). On the other hand

CXDT could reduce the trend of the whole blood relative index. Conclusion: Chuanxiong Dingtong grainules has the effect of promoting blood circulation.