Objective: To study the antiobesity function of the orlistat on diet-induced obese rats. Method: SD rats were randomized on the basis of their body weight and divided into control group

model group and orlistat group. Control group was fed with normal diet

model group and orlistat group was fed with nutritional diet. Orlistat group was administered for 7 weeks through the route of intragastric administration of orlistat(60 mg·kg-1) along with nutritional diet. Control group and model group were administered with 0.5% CMC-Na. The body weight

Lee's index

body fat

body fat/body weight and liver weight were measured. Result: The body weight [(306.52±37.02)g→(266.11±21.55)g

P<0.05]

Lee's index [(309.45±7.25)→(301.34±6.69)

P<0.05]

body fat [(9.84±2.95)g→(4.67±1.98)g

P<0.05]

and liver weight [(9.95±2.66)g→(7.61±1.08)g

P<0.05] of orlistat group significantly reduced compared to model group. Conclusion: Orlistat could significantly decrease body weight

liver weight

body fat and Lee's index of obese rats. The antiobesity function of the orlistat is significant.