Objective: To investigate the influence of Lycium bararum polysaccharide (LBP) and LBP with interferon-inducible protein 10(CXCL10) on the differentiation of helper T cells in bearing mice. Method: H22 bearing mice model was established and randomized into six groups: the model group

high-and low dose group

LBP with CXCL10 group

CTX group

control group. Serum was separated from eye ball after two weeks of treatment. tumors

spleen

thymus were separated and calculated anti-tumor rate

thymus index and spleen index. Flow cytometry was used to detect the differentiation of Th1/Th2 in mice peripheral blood. Result: Compared with model group

tumor inhibitory rate in low-and high dose group

LBP with CXCL10 group was 37.83%

12.50%

14.14%; the rate of Th1/Th2 was 4.44±3.05

2.48±2.93

4.36±1.96

among them LBP low dose group and LBP with CXCL10 group was obvious(P<0.05). Conclusion: Low dose of LBP and LBP with CXCL10 can increase the rate of Th1/Th2 markedly in bearing mice.