Objective: To investigate the effect of Baogan tablets against CCl4 complex factors induced hepatic fibrosis in rats. Method: The SD rat were divided into six groups randomly: control group (NC)

hepatic fibrosis model group

3 different does drug group (27.55

13.78

6.89 g·kg-1) of Baogan tablets and a positive control group (colchicine tablets 0.2 mg·kg-1).The rats of NC group were given normal saline

the other group were induced by CCl4 complex factors. At the same time

the other groups were treated by Baogan tablets and colchicine tablets. The effects of drugs were observed by calculating the liver index

detecting liver function alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

albumin(ALB) and observing the extent of liver fibrosis. Result: Compared with control group

the content of AST

ALT in serum

liver index

and the extent of liver fibrosis were increased significantly

ALB was decreased in the model group(P<0.01). Compared with the model group

the content of ALB in serum was increased significantly (P<0.01)

and the extent of liver fibrosis was lessened significantly in the drug group (27.55 g·kg-1

P<0.05). Conclusion: Baogan tablets could improve the degree of liver fibrosis in rats.