Objective: To investigate the effects of Yixinnao dripping pills on platelet aggregation and thrombus formation in rats

as well as the effects on coagulability activity. Method: The Wistar rats were divided into normal control group

aspirin group

Yixinnao dripping pills high

middle and low dose group(906

453

226 mg·kg-1

ig

accordingly). The effects of Yixinnao dripping pills on platelet aggregation in vivo were measured by the model induced by ADP

thrombin and CaCl2.Coagulation time in acute blood stasis rat models was determined by the glass capillary method and the effects were also evaluated on prothrombin time (PT) and thrombin time (TT) in these groups. The inhibitory action of Yixinnao dripping pills on the thrombus formation was investigated by the model of artery-vein bypass thrombosis. Result: Yixinnao dripping pills in the high

middle and low dose could signifiinhibit platelet aggregation induced by ADP

thrombin and CaCl2

respectly (P<0.05 or P<0.01). It could also lengthen coagulation time

TT and PT in different degree (P<0.05 or P<0.01).Moreover

Yixinnao dripping pills (906

453 mg·kg-1) could markedly restrain thrombus formation

reduce thrombus weight (P<0.05 or P<0.01). Conclusion: Yixinnao dripping pills showed the function of anti-thrombosis

and exerted the effects on inhibition of platelet aggregation and coagulability.