WANG Lan, LI Chun, YANG Lian-ju, et al. Pharmacodynamic Comparison between Wild and Breeding Faeces Trogopterori[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 268-271.
WANG Lan, LI Chun, YANG Lian-ju, et al. Pharmacodynamic Comparison between Wild and Breeding Faeces Trogopterori[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 268-271. DOI: 10.11653/zgsyfjxzz2013070268.
Objective: To observe the effects between Wild and Breeding double teeth mole Faeces Trogopterori on removing blood stasis
anti-inflammatory in rat with acute blood stasis syndrome and paw edema inflammation. Method: Rats were randomly divided into 8 groups for anti-inflammation test: model control group
positive medicine group (aspirin 0.2 g·kg-1)
shannxi Faeces Trogopterori of higher
middle and low dosage groups (9
4.5
2.25 g·kg-1)
wild Faeces Trogopterori of higher
middle and low dosage groups (9
4.5
2.25 g·kg-1). All groups were treated continuously for 7 days. Rats were randomly divided into 9 groups for activating-blood: normal control group
model control group
positive group (aspirin 0.05 g·kg-1) and 6 treatment groups which use the same dose and time to the anti-inflammation test. After treatment
carrageenan was injected subcutaneously in the pad of the rat's hindfoot.The volume of the rat's hindfoot was measured at 30 min
1
2
4 h
and 6 h respectively after the modeling
and the degrees of swelling(E%). The indexes of hemorheology including whole blood viscosity under different shear rates
packed cell volume
plasma viscosity
platelet aggregation and fibrinogen were detected for the rat blood stasis syndrome model. Result: All the treatment groups showed the strongest effect after treatment for 1 h. Faeces Trogopterori from Shannxi had the lasting action time. Higher dosage still showed
an obviously decreasing digits swelling degree after 6 h. There was no significant effect of from shaanxi on blood rheology indexes
and whole blood viscosity could be decreased by wild Faeces Trogopterori. Conclusion: The effect of breeding Faeces Trogopterori on anti-inflammatory was better than the wild
but there was no significant effect on removing blood stasis.