Objective: To observe the effects of Zhengan Xifeng granule on insulin sensitivity

blood pressure

blood glucose and blood lipid in hypertension patients. Method: Sixty-six hyper-tension patients with insulin resistance were randomly divided into treatment group (cooperation of chinese and western medicine group) and control group(western medicine group). Each group was treated for 6 months and then the blood pressure (BP)

fasting blood glucose (FBG)

total cholesterol (TC)

the triglyceride (TG)

low-or high-density lipoprotein-cholesterol (LDL-C or HDL-C)

free fatty acids

as well as insulin sensitivity index (ISI) were measured. Result: Compared to the control group

the contents of the treatment group were significantly improved as follow:BP decreased(P<0.01)

FBG

TC

TG

LDL-C and FFA lowered

HDL-C increased(P<0.05) and the ISl weakened(P<0.05). Conclusion: Zhengan Xifeng granule appeared to decrease blood pressure

stable the blood glucose and blood fat

suppress insulin resistance

enhance the insulin sensitivity as well as modify hyperinsulinemia.