Objective: To investigate the effects of traditional Chinese(TCM) medicine therapy on plasminogen activator(t-PA)

plasminogen activator inhibitor(PAI-1) to chronic renal failure(CFR) patients and its intervention way. Method: The patients of chronic kidney disease(CKD) 4 were randomly divided into 4 groups: western medicine group

western medicine with herbs group

western medicine with herbs and clysis group

and western medicine with herbs

clysis and fumigation group

and treated with the medicine respectively.In the third month

serum creatinine

blood urea nitrogen

plasma t-PA and PAI-1 were detected before and after treatment. Result: In TCM treatments

the levels of plasma PAI-1 were decreased

renal function was improved

and the levels of plasma t-PA were increased significantly as compared to western medicine group(P<0.05).The 4th group decreased the levels of serum creatinine

blood urea nitrogen and increased the levels of plasma t-PA bestly(P<0.05)

but there were no significant differences among the three groups about the decreasing of plasma PAI-1. Conclusion: TCM treatments could intervent CRF by modulating the activity of fibrinolytic system.