Objective: To explore the clinical curative effect on Jiawei Yigan san (JYS) for treatment of infantile fastidium. Method: Eighty-three cases of children with infantile fastidium were randomly divided into the observation group (n=42) and the control group (n=41). The control group was given the pediatric Jianpi Huaji oral liquid (2-3 years old 5-10 mL

tid;>3 years old 10 mL

tid). The observation group was received JYS

1 dose of tap water decoction (divided in a few portions to take) daily. The treatment lasted for 4 weeks. Serum trace elements Zn and serum neuropeptide Y (NPY) were investigated before and after the treatment. Result: Serum Zn level in the observation group was slightly higher than that in the control group. Serum NPY level in two groups was increased; compared with that before treatment

it was more significant in the observation group (P<0.01). After treatment

the total effective rate in the observation group was 97.62%

higher than that of 82.93% in the control group (P<0.05). After treatment

the score for liver and spleen syndrome in the observation group was (2.5±2.4) which was lower than (7.6±3.2) in the control group (P<0.01). In two groups

body mass index (BMI) after therapy was increased compared with that before treatment (P<0.01)

the increase in observation group was higher than that in the control group (P<0.05).After treatment

the total effective rate in the observation group syndrome was 97.62%

which was higher than 80.49% in the control group (P<0.05). Conclusion: Treatment of JYS can increase BMI

food intake and serum NPY level. It has good therapeutic effect for infantile fastidium.