Objective: To observe the effect of salvianolate injection on cardiac function

high sensitivity C reactive protein (hs-CRP)

tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in patients with chronic heart failure (CHF). Method: Eighty cases of CHF were randomly divided into the observation group and control group

40 cases each. The control group was only received western medicine therapy

and the observation group was received western medicine therapy and salvianolate injection (200 mg in 5% glucose injection of 250 mL) iv dropping. The course of treatment of two groups was 14 days. Lee's heart failure score method was used to evaluate cardiac function. The termination and decreasing condition of digoxin was recorded

and hs-CRP

TNF-α and IL-6 were determined. Result: There was obvious difference in effective rate between observation group (95.0%) and control group (77.5%) for heart failure (P<0.05). The LVEF in the observation group (51.3±4.18)% was superior to that in the control group (47.2±4.27)% with a statistical significance (P<0.01). The terminating and decreasing rate of digoxin was 82.5% in the observation group

which was superior to 57.5% in the control group (P<0.05). After treatment

hs-CRP

TNF-α and IL-6 in the observation group were lower than those in the control group (P<0.01). Conclusion: Salvianolate injection can improve cardiac function in the patients with CHF

reduce the dosages of Western medicines

possess good clinical efficacy

resist inflammatory factors (hs-CRP

TNF-α and IL-6)

and reduce myocardial injury.