Objective: To describe the efficacy of Modified Xuefu Zhuyu decoction (MXZD) on patients with acute pulmonary contusion and its effect on endothelin (ET-1)

interlukin-8 (IL-8) and C-reactive protein (CRP). Method: Eighty-four patients with acute pulmonary contusion were divided into two groups randomly: observation group and control group (n=42 each). In control group

the patients were treated only with routine therapy. In observation group

they were prescribed with MXZD (one dose daily). Clinical symptom

blood gas

mechanical ventilation rate

lung infection rate

acute respiratory distress syndrome (ARDS) rate

death rates and serum ET-1

IL-8 and CRP were observed and analyzed. Result: After treatment

the clinical stages of the observation group were lower than that of control group (P<0.05). PO2

PCO2 and PO2/FiO2 in the observation group were significantly higher than those in control group (P<0.05

P<0.01). Compared with the control group

the mechanical ventilation rate and lung infection rate in the observation group were lower without a statistical significance

while ET-1

IL-8 and CRP in the observation group were significantly lower (P<0.05

P<0.01). Conclusion: MXZD can diminish clinical symptoms of acute pulmonary contusion

decrease plasma ET-1

IL-8 and CRP

increase PO2

PCO2 and PO2/FiO2

and improve the recovery of pulmonary function caused by pulmonary contusion.