Objective: To study the influence of Fuzheng Shugan Xiaoai decoction (FSXD) on relapse

metastasis and life quality in breast cancer patients with postoperative radiation and chemotherapy. Method: Eighty-two cases of breast cancer patients after modified radical mastectomy were randomly divided into the observation group (n=43) and the control group (n=39). The control group was given routine western medicine symptomatic treatment. Except the routine symptomatic treatment

the observation group was given FSXD

1 dose daily right after radiotherapy or/and chemotherapy until 3 months after the ending of those therapies. Afterwards

4-7 doses of FSXD per week were given to a patient for 1 year. Generally

a dose of FSXD was decocted and divided in half for 2 services daily. When decoction was inconvenient for some patients

the formulated granules were given. The life quality

the main symptoms and signs

relapse and metastasis were recorded. Vascular endothelial growth factor (VEGF) was determined for the patients. Result: After 6

12 months of treatment

the overall health scores in the observation group were higher than those in the control group (P<0.01). After 6

12 months of treatment

the overall life quality in the observation group was higher than that in the control group (P<0.01). After the ending of radiotherapy and chemotherapy

additional treatment of FXSD for 6

12 months the main symptoms and signs in observation group were lower than those in the control group (P<0.01). The serum VEGF levels in the observation group after treatment of 6 and 12 months were lower than those in the control group

the difference was significant (P<0.05

P<0.01). Conclusion: FSXD can reduce the main symptoms and signs for breast cancer patients with postoperative radiotherapy and chemotherapy

improve the quality of life for the patients

and reduce serum VEGF level. Therefore

FSXD may prevent the recurrence and metastasis of the cancer.