Objective: To review the research on monomer components of Chinese materia medica for immunoregulation of chronic hepatitis B. Method: The articles related to monomer components of Chinese materia medica for immunoregulation of chronic hepatitis B in CNKI database and PubMed Database from January 2000 to September 2012 were retrieved with the key words of'Chronic hepatitis B

monomer components of Chinese materia medica

mmunoregulation'. A total of 126 literatures were obtained from computer screen

and 45 documents of them were involved for summarization. Result: A lot of monomer components of Chinese materia medica has been screened

for example

root of whitebackleaf mallotus

astragaloside IV

homobarringtonie. The mechanisms is closely related with inhibiting HBVDNA replication

regulating the balance of Thl/Th2 cell factors

promoting the maturation of dendritic cell

regulating the express of Toll-like receptor

regulating the singal of hepatocyte apoptosis. Conclusion: The monomer components of Chinese materia medica play an key role in immunoregulation of chronic hepatitis B.But there are some problem need to be solved

for example

the control of herb resource and preparation

the lack of study on evidence based medicine in large sample and long term effect research. It is heavy responsibility to deal with these problems.