Objective: To optimize extraction process of Qidan granules. Method: Taking tanshinone ⅡA content

salvianolic acid B content and dry extract rate as indexes

orthogonal test was adopted to optimize alcohol extraction process with extraction times

the concentration and consumption of ethanol as factors;With dry extract rate and extracting amount of astragaloside as indexes

orthogonal test was adopted to investigate effects of the amount of water

boiling time and decocting times on water extraction process.Contents of astragaloside

salvianolic acid B and tanshinone ⅡA were determined by HPLC. Result: Optimum alcohol extraction conditions were as follows:extracted twice with six times the amount of 60% ethanol

extraction time of 2

1 h;Dry extract rate was 41.04%

mass fraction of salvianolic acid B and tanshinone ⅡA were 1.215% and 0.599%

respectively.Optimum water extraction conditions were as follows:decocted twice with ten times the volume of water

1.5 h per time;Extracting amount of astragaloside was 3.408 mg·g-1

dry extract rate was 43.37%. Conclusion: Optimized extraction process was stable and feasible

which could provide a reference for rational development of Qidan granules.