Objective: To observe effects of ethanol extraction from Cassiae Semen on serum interleukin-6(IL-6) and tumour necrosis factor-α (TNF-α) in hyperlipidemia rats. Method: The rat hyperlipidemia model was established by feeding high calorie-diet and 10% alcohol. After modeling

the selected rats were randomly divided into six groups:normal control group

model group

positive control group

low dose group

medium dose group and high dose group. Positive control group was administrated Xuezhikang capsule at dose of 0.15 g·kg-1. Low dose group

medium dose group and high dose group were administrated at different concentrations of ethanol extraction from Cassiae Semen

which was respectively 4

8

16 g·kg-1. All groups were applied by intragastric administration by 10 mL·kg-1 for 4 weeks. Except normal control group

the remains were fed with high calorie-diet and 10% alcohol. After the last administration

the serum content of total cholesterol (TC)

triglyceride(TG)

low-density lipoprotein-cholesterol(LDL-C)

high-density lipoprotein-cholesterol(HDL-C) and glucose(Glu) were detected by automated biochemistry analyzer. And the content of IL-6 and TNF-α was determined by ELISA. Result: The content of TC

TG

LDL-C

Glu

IL-6 and TNF-α was increased

and the content of HDL-C was decreased in model group

compared with normal control group (P<0.01).The content of TC

TG

LDL-C and Glu was decreased

and the content of HDL-C was increased in medium dose group and high dose group of ethanol extraction from Cassiae Semen

compared with model group (P<0.01). At the same time

the content of IL-6 and TNF-α was decreased in medium dose group and high dose group (P<0.01). Conclusion: Ethanol extraction from Cassiae Semen can regulate the metabolic process of blood lipids and blood glucose levels of hyperlipidemia model rats

also can decrease the content of IL-6 and TNF-α in serum.