Objective: To explore the effects of breviscapine on immunological function of acute exacerbation chronic obstructive pulmonary disease(AECOPD). Method: Sixty cases with AECOPD were randomly divided into the treatment group and control group. In addition to routine comprehensive treatment in both groups

additional 40 mg breviscapine was given to the treatment group by intravenously guttae

once per for fourteen days. The effects of treatment and the change of pulmonary function and CD3

CD4

CD8

CD4/CD8 in peripheral blood were observed. Result: The effective rate was significantly increased in treatment group (P<0.05). The improved levels of FEV1/FVC

FEV1

FVC

PEF

RV and RV/TLC were significantly increased in treatment group than control group (P<0.05). The levels of CD3

CD4 significantly increased and CD8

CD4/CD8 descended in treatment group. There were no significantly changed in control group. Conclusion: On the basis of routine comprehensive treatment combined with breviscapine can improve the curative effect in AECOPD. It may concern with that breviscapine can obviously improve immunological function of T lymphocyte.