Objective: To observe the effects of Xingnaojing(xnjj) on the Pathogenesis of the soluble intercellular adhesion molecule1 (s ICAM-1)

tumor necrosis factor(TNF-α) and interleukin-1β(IL-1β)in the patients with cerebral vasospasm (CVS) after spontaneous subarachnoid hemorrhage (SAH). Method: Sixty-two patients with SAH were randomly assigned to the puerarin group (32 cases) and the control group (30 cases) by lot.On the basis of routine treatment

the patients in the xnjj group were intravenously dripped with 30 mL puerarin by adding in 250 mL normal saline injection once daily.The injection was given starting from beginning the disease course

for 14 successive days.The serum levels of s ICAM-1

TNF-α and IL-1β were compared between the two groups pre and post treatment.The incidence of CVS was observed using TCD.The glasgow outcome scale (GOS) were compared between the two groups. Result: Compared with the control group

the serum levels of hs-CRP

s ICAM-1

TNF-α and IL-1β decreased in the xnjj group(P<0.05)

the mean middle cerebral artery(MCA)

anterior cerebral artery (ACA) and posterior cerebral arteries(PCA)velocity decreased (P<0.05)

and the GOS increased(P<0.05). Conclusion: The Pathogenesis of Xingnaojing on the patients with CVS after SAH might were decreased the levels of sICAM-1

TNF-α and IL-1β

decreased the cerebral blood flow

and decelerate cerebral blood velocity

absolve cerebral vascular convulsion.It was an effective agent for treatment of the CVS in patients after SAH.