Objective: The purpose is to observe the clinical effects of Sancai Fengsui dan coordinated with Daochi san to treat recurrent oral ulceration(RAU) and influence of T cell subset

inflammatory factor. Method: One hundred and five cases of patients with were randomly divided into control group (52 cases) and observation group (53 cases) by digital method.For patients in control group

they took licorzine granules

5 g/time

3 times/day

taken orally.Treatment course were 8 weeks.Besides

they took Vitamin B2 piece

5 mg/time

3 times/day

taken orally

continuing 8 weeks.Vitamin C tablets

0.2 g/time

3 times/day

continuing 4 weeks.Coat ulcer surface with Bingpeng san

3-6 times/day

continuing 5 days.Based on control group

patients in observation group took Sancai Fengsui Dan and Daochi san by dialectical add and subtract treatment

orally

1 does/day

water conventionally.Treatment course were 8 weeks.For short-term effects

choose ulcer area

degree of congestion and pain as observation target.Observe recurrence rate during 3

6 months.Detect peripheral blood T lymphocyte subsets (CD3+

CD4+

CD8+

CD4+/CD8+) before and after treatments. Test the level of interleukin-2 (IL-2)

interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α). Result: Analyzed by Ridit

the curative effect of the observation group was superior to the control group(P<0.05)

the fifth day after the treatment

the main symptoms and total symptom score of the observation group were lower than these data of observation group

besides

the ulcer area and the hyperemic area of the observation group were smaller than the observation group(P<0.01)

During the three mouths after the treatment

it showed no statistically significant of the recurrence rate among the two groups

After 6 mouths of the treatment

the recurrence rate of the control group 55.8% was higher than 26.4% of the observation group(P<0.01)

CD3+

CD4+ and CD4+/CD8+ of the observation group were higher than the control group.The observation group was lower than the CD8+ of control group(P<0.05 or P<0.01)

Serum interleukin-2 of the observation group was higher than the control group(P<0.01)

IL-10 and TNF-α of the observation group were lower than the control group(P<0.01). Conclusion: On the base of western medical routine therapy

it can relief the clinical symptoms quickly and reduce the recurrence rate when Sancai Fengsui dan which combined with Daochi san was use for curing recurrent aphthous stomatitis

besides

there was a obvious curative effect in short-term and long-term

the mechanism of action may be related to regulating the T lymphocyte subpopulation and the level of relative inflammatory factors

and improving the unbalanced immune function.