This paper discusses the penetration methods and its combination research progress of transdermal drug delivery system. Search the recent years domestic and foreign literature on TDDS

the penetration mechanism of Nano drug carrier systems

physical methods and the combination research progress are introduced in this paper. The use of transdermal penetration methods in TDDS

improve the poor skin permeability of the drug and overcome the problems of the skin stratum corneum barrier. Furthermore

the combinations of several methods is much better than any other one

promote the development of TDDS. TDDS has the advantage of no first-pass effect

stable plasma concentration and little drug side effects. In recent years

a variety of new methods and technologies had been used in TDDS to enhance drug penetration

making it becomes possible that the majority of drug to develop transdermal formulations

the research of transdermal penetration methods combination and its mechanism should be strengthened in future

expecting to promote the development of transdermal formulations.