Objective: To study powder properties of Faeces Trogopterori and investigate relativity between powder properties and in vitro dissolution behavior. Method: Faeces Trogopterori was crushed by vibration type low temperature ultrafine pulverizer

sampling every 3 min

particle size

specific surface area and porosity of samples were detected;With the content of total flavonoids as index

in vitro dissolution rate of Faeces Trogopterori powder was investigated

relativity between powder properties and in vitro dissolution behavior was analyzed. Result: With increasing grinding time

particle size decreased

specific surface area and in vitrodissolution rate increased;Powder size and in vitro dissolution rate had a good correlation.Grinding time of Faeces Trogopterori selected 21 min

but particle size of d0.9 should choose was about 100 μm. Conclusion: After low-temperature ultrafine ground of Faeces Trogopterori

particle morphology and structurewas uniform with high dissolution rate

which was helpful forits subsequent evaluation of preparation process and quality control.