Objective: To study the effect and mechanism of ginsenosides Rb1 on memory impairment of type 2 diabetes. Method: C57BL mice were as normal control group and Kkay mice with high blood sugar as model l group. The model mice were divided into positive group and composite group with high

middle and low dose. The positive group was treated with Rosiglitazone maleate tablets(0.003 g·kg-1)ig

and composite group was given the same Rosiglitazone tablets and ginsenosides Rb1 (0.06

0.03

0.015 g·kg-1) ig. After Morris water mazeimmunohistochemistry was used to assay 1-phosphatidy linosital 3-kinase(PI-3K)/Akt

and Western blotting was used to detect glycogen synthase kinase-3β GSK-3β

and p-Tau and insulin receptor(INSR) level. Result: INSR levels were almost the same in every group.Compared with normal control group

model group had more active PI-3K/Akt and lower GSK-3β and p-Tau level. Howere

compared with control group

there was no significant differences in positive group

while PI-3K/Akt was more active

and GSK-3β and p-Tau was contrary in composite group. Conclusion: Ginsenosides Rb1 can improve the memory of type 2 diabetes mice

the possible mechanism may be related to improving insulin signaling pathway.