Objective: Analyzing the literature on guinea pig usage for allergic rhinitis research

in order to determine the best evaluation model. Method: China Hospital Knowledge Database (CHKD) was used to search the terms ‘allergic rhinitis’ and ‘guinea pig’ in the period between 1979 and 2013. Result: A total of 208 articles were found

of which 51 articles described the model evaluation methods

which included behavior score

nasal secretions smear

passive cutaneous anaphylaxis (PCA)

and pathological observation. Conclusion: Behavioral score evaluation method is the most commonly used

currently the method proposed by Zhao is more fairly reliable

but there is not uniform standard on procedure. On this basis

combined with nasal secretions smear

and PCA evaluation model is more reliable

but for PCA and pathology observation there is the need to increase the number of animals

thus making it difficult to operate. Therefore

the current literature still does not provide adequate support for the best model evaluation method.