In this paper

We performed a analysis andsummaryof numerous published papers about Chinese medicine NPs'targeted therapy in Hepatocellular carcinoma( HCC)from three aspects: focusing on the passive targeting

active targeting and physicochemical targetingagents

especially the mechanisms and methods. We also give a discussion and outlook about the further development of Chinese medicine NPs'drug delivery systems in HCC. (HCC) is a kind of malignancy with high morbidity and mortality

Due to the drug' poor selectivity to tumor

low absorption and the emergence of multidrug resistance clinically

the effect of chemotherapy in patients with liver cancer is not ideal. Where the chinese medicine play a significant role

The chinese medicine nanoparticles(NPs) combineing the advantages of nano-medicine and nano-medicine

solve the above problems effectively

show a wealth of potential applications in the treatment of liver cancer

and become the hot spot in HCC targeted therapy nowadays.