Objective: To investigate effects of different dissolution conditions on dissolution characteristics of baicalin solid dispersions. Method: Baicalin-PEG6000 solid dispersions was prepared by solvent evaporation method

DSC and X-ray diffraction method were adopted to identify its formation

and effects of different conditions on its in vitro dissolution were investigated. Result: Baicalin was in amorphous form dispersed in solid dispersions;Stripping properties of baicalin solid dispersions in different kinds of stripping method were different;In pure water medium

release of baicalin was 65% in 15 min

then release slow increased

released more than 70% in 330 min;In artificial gastric juice

it released 30% in 15 min and 56% in 330 min;In simulated gastrointestinal medium

it released slowly in the stomach environment (released 30%-54% in 15-120 min) and released quickly in the small intestine environment (released 54%-69% in 120-330 min). Conclusion: Dissolution properties of baicalin-PEG6000 solid dispersions in different dissolution methods were different

dynamic dissolution medium should be widely applied.