Objective: To study secondary metabolites of mangrove endophytic fungus No·ZH-4d from the south china sea. Method: The compounds were isolated by column chromatography and identified on the basia of physic-chemical constants and spectral analysis. Result: Six metabolites were obtained and elucidated as citrinin (1)

tenellic acid C (2)

tenellic acid A (3)

terretonin (4)

echinulin (5)

(E) -4

6-dimethoxy-3-[4-oxo-5-(prop-1-enyl)-4H-pyran-2-yl]-isobenzofuran-1 (3H)-one (6). In the preliminary bioassay

1 show strong inhibittory activity on the KB

KBv200 with IC50 values of 0.08

0.09 mmol·L-1

respectively. Conclusion: The six metabolites were obtained from endophytic fungus No·ZH-4d for the first time.