Objective: To study the pharmacokinetics research on ophiopogonins components in rats. The acquisitions in this paper include the standard curve of ophiopogonins in rat plasma and linear range

the description of concentration-time curve of ophiopogonins and the calculation of pharmacokinetic parameters of ophiopogonins. Method: The pharmacokinetics research on phiopogonins in rat was conducted by means of intravenous injection and intragastric administration. Intravenous injection dose of ophiopogon japonicus extract at 200 mg·kg-1 was applied to each rat through the tail vein. Serial blood samples were collected in heparinized tubes from the orbital sinus. Pharmacokinetic parameters in rat plasma were calculated by compartmental models using the WinNonlin 6.1 software. Result: 5 minutes after the intravenous injection

50 types of ophiopogonins components were detected in the plasma of rat

and 28 of them were calculated to pharmacokinetic coefficients. Conclusion: According to the result of proportion and plasma exposure

the ophiopogonins components show differential pharmacokinetics characteristics. Based on the relative exposure approach

pharmacokinetic coefficients are e obtained. The results suggested that part of ophiopogonins components has high exposure level in rat plasma and possess high area under curve (AUC)

while the other types of ophiopogonins has relative low exposure level and low AUC.